I ka wā maʻi maʻi, ke hoʻohana nei nā kauka i nā antibodies monoclonal transfused (laboratory-produced antibodies) e kōkua i nā maʻi e hakakā i ka maʻi COVID-19. I kēia manawa ke hoʻāʻo nei nā mea noiʻi UC Davis e hana i nā antibodies monoclonal i hiki ke kōkua i ke kaua ʻana i ka ʻeha mau loa. ʻO ka pahuhopu ka hoʻomohala ʻana i kahi mea hōʻeha ʻeha mahina ʻole i hiki ke pani i nā opioids.
Ke alakaʻiʻia nei ka papahana e Vladimir Yarov-Yarovoi lāuaʻo James Trimmer, nā kumu aʻo ma ke Keʻena o Physiology a me Biology of Membrane ma ke Kulanui o Kaleponi, Davis School of Medicine. Ua hōʻuluʻulu lākou i kahi hui multidisciplinary i komo pū me nā mea noiʻi like ʻole e hoʻāʻo nei e hoʻohuli i ka lāʻau tarantula i mau lāʻau ʻeha.
Ma mua o kēia makahiki, ua loaʻa iā Yarov-Yarovoy lāua ʻo Trimmer kahi haʻawina $1.5 miliona mai ka papahana HEAL o ka National Institutes of Health, kahi hoʻāʻo ikaika e hoʻolalelale i nā ʻepekema ʻepekema e loaʻa ai ka pilikia opioid o ka ʻāina.
Ma muli o ka ʻeha mau loa, hiki i nā kānaka ke lilo i ka opioids. Manaʻo nā Centers for Disease Control's National Center for Health Statistics he 107,622 mau make overdose ma United States i 2021, kokoke i 15% ʻoi aku ma mua o ka 93,655 mau make ma 2020.
"ʻO nā holomua hou i ka biology structural and computational biology - ka hoʻohana ʻana i nā kamepiula e hoʻomaopopo a hoʻohālike i nā ʻōnaehana biological - ua kau i ke kumu no ka hoʻohana ʻana i nā ala hou no ka hana ʻana i nā antibodies e like me nā moho lāʻau lapaʻau maikaʻi loa no ka mālama ʻana i ka ʻeha mau loa," wahi a Yarov. ʻO Yarovoy, ka mea hoʻokani nui o ka makana Sai.
"ʻO nā antibodies monoclonal ka wahi ulu wikiwiki loa o ka ʻoihana lāʻau lapaʻau a hāʻawi i nā pono he nui ma mua o nā lāʻau mole liʻiliʻi liʻiliʻi," wahi a Trimmer. ʻO nā lāʻau mole liʻiliʻi nā lāʻau lapaʻau e komo maʻalahi i nā cell. Hoʻohana nui ʻia lākou i ka lāʻau lapaʻau.
I loko o nā makahiki, ua hana ʻo Trimmer's lab i mau kaukani monoclonal antibodies no nā kumu like ʻole, akā ʻo kēia ka hoʻāʻo mua e hana i kahi antibody i hoʻolālā ʻia e hoʻomaha i ka ʻeha.
ʻOiai ke nānā aku nei he futuristic, ua ʻae ka US Food and Drug Administration i nā antibodies monoclonal no ka mālama ʻana a me ka pale ʻana i ka migraine. Ke hana nei nā lāʻau lapaʻau hou i kahi protein e pili ana me ka migraine i kapa ʻia ʻo ka calcitonin gene-related peptide.
He pahuhopu ʻokoʻa ko ka papahana UC Davis - nā kaila ion kikoʻī i loko o nā pūnaewele nerve i kapa ʻia nā kahawai sodium-gated. Ua like kēia mau auwai me nā "pores" ma nā pūnana nerve.
"ʻO nā pūnaewele nerve ke kuleana no ka lawe ʻana i nā hōʻailona ʻeha i ke kino. ʻO nā kaila sodium ion i hoʻopaʻa ʻia i loko o nā pūnaewele nerve nā mea hoʻouna nui o ka ʻeha, "wahi a Yarov-Yarovoy. "ʻO kā mākou pahuhopu ka hana ʻana i nā antibodies e hoʻopaʻa i kēia mau pūnaewele hoʻouna kikoʻī ma ka pae mole, pale i kā lākou hana a pale i ka lawe ʻana i nā hōʻailona ʻeha."
Ua nānā ka poʻe noiʻi i ʻekolu mau kaila sodium kikoʻī e pili ana i ka ʻeha: NaV1.7, NaV1.8, a me NaV1.9.
ʻO kā lākou pahuhopu ka hana ʻana i nā antibodies e pili ana i kēia mau ala, e like me ke kī e wehe ana i kahi laka. Hoʻolālā ʻia kēia ala i hoʻopaʻa ʻia e pale i ka hoʻouna ʻana i nā hōʻailona ʻeha ma o ke kahawai me ka ʻole e hoʻopilikia i nā hōʻailona ʻē aʻe i hoʻouna ʻia ma o nā pūnaewele nerve.
ʻO ka pilikia, ʻo ia ka paʻakikī o ke ʻano o nā kahawai ʻekolu a lākou e hoʻāʻo nei e pale.
No ka hoʻoponopono ʻana i kēia pilikia, huli lākou i nā polokalamu Rosetta a me AlphaFold. Me Rosetta, ke hoʻomohala nei nā mea noiʻi i nā hiʻohiʻona protein virtual paʻakikī a me ka nānā ʻana i nā hiʻohiʻona i kūpono i nā ala neural NaV1.7, NaV1.8, a me NaV1.9. Me AlphaFold, hiki i nā mea noiʻi ke hoʻāʻo kūʻokoʻa i nā protein i hoʻomohala ʻia e Rosetta.
I ka manawa i ʻike ai lākou i kekahi mau protein hoʻohiki, hana lākou i nā antibodies i hiki ke hoʻāʻo ʻia ma nā ʻiʻo neural i hana ʻia i loko o ka lab. He mau makahiki ka hoao ana o kanaka.
Akā, hauʻoli nā mea noiʻi e pili ana i ka hiki o kēia ala hou. ʻO nā lāʻau anti-inflammatory non-steroidal (NSAIDs), e like me ka ibuprofen a me ka acetaminophen, pono e lawe pinepine i ka lā e hoʻomaha i ka ʻeha. Lawe pinepine ʻia nā lāʻau lapaʻau opioid i kēlā me kēia lā a lawe i kahi pilikia o ka addiction.
Eia naʻe, hiki i nā antibodies monoclonal ke holo i loko o ke koko no hoʻokahi mahina ma mua o ka wāwahi ʻia ʻana e ke kino. Ua manaʻo ka poʻe noiʻi i nā mea maʻi e hoʻokele iā lākou iho i ka analgesic monoclonal antibody i hoʻokahi mahina.
"No nā poʻe maʻi me ka ʻeha mau, ʻo ia ka mea āu e pono ai," wahi a Yarov-Yarovoy. "ʻAʻole lākou e ʻeha no nā lā, akā no nā pule a me nā mahina. Manaʻo ʻia e hiki i nā antibodies ke hoʻolako i ka hōʻeha ʻeha e mau ana no kekahi mau pule. "
ʻO nā lālā ʻē aʻe o EPFL ʻo Bruno Correia, Yale's Steven Waxman, EicOsis' William Schmidt a me Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, a me Robert Stewart o UC Davis.
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Ka manawa hoʻouna: Sep-29-2022